Autoimmunity Diabetes

Autoimmunity Diabetes - Autoimmunity Diabetes (Type 1)...

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Autoimmunity Diabetes (Type 1) Diabetes Mellitus: Type 1 (an organ specific autoimmune disease) IDDM is a state of chronic hyperglycaemia sufficient to cause long term damage to specific tissues, notably the retina, kidneys, nerves and arteries. It is caused by T cell destruction of beta cells in the pancreas which results in insulin deficiency. It is usually picked up in young adults once the autoimmune damage has occurred. The pancreas of newly diagnosed patients is infiltrated with Tc cells. There are circulating antibodies to islet cell in 85% of newly diagnosed patients. There is a HLA association with HLA-DR 3 or HLA-DR-4. This HLA association is present in >90% of patients with IDDM. There is additionally an association with other autoimmune diseases such as Addison’s diseases. Pathogenesis of Type 1 DM (the theory) 1. Infectious or environmental agent damages the pancreas 2. In genetically susceptible individuals autoimmune T and B cells respond to beta cells 3. Irreversible destruction of beta cells leading to insulin deficiency
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This note was uploaded on 12/04/2011 for the course ANTHRO 2000 taught by Professor Monicaoyola during the Fall '10 term at Broward College.

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Autoimmunity Diabetes - Autoimmunity Diabetes (Type 1)...

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