Autoimmunity - Autoimmunity This article describes...

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Autoimmunity This article describes autoimmunity and autoimmune disease. Introduction Definitions Autoimmunity – an immune reaction to self Autoimmune disease – a clinical disease/pathology resulting from an autoimmune reaction Prevalence of Autoimmunity Autoimmune thyroid disease up to 3% adult women Rheumatoid arthritis ~1% adult population Diabetes mellitus-type 1 ~1% population Multiple sclerosis ~0.1% UK population Classification of Autoimmune Diseases Organ Specific Immune response directed at local antigen’s – Graves Disease Systemic / Multisystem Immune response targeted at system wide antigens such as RF seen in RA Mechanisms of Autoimmunity Which parts of the immune system are involved? B cells autoantibodies T cells auto reactive T cells Cytokines activate other cells of immune system Complement hereditary complement deficiencies associated with autoimmunity B cells are involved with pathogenesis of autoimmunity 1. Antibodies transfer disease to infants of affected mother’s e.g. neonatal lupus
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Autoimmunity - Autoimmunity This article describes...

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