Benign prostatic hyperplasia

Benign prostatic hyperplasia - Benign prostatic...

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Benign prostatic hyperplasia (BPH) Causes Most experts consider androgens (testosterone and related hormones) to play a permissive role. This means that androgens have to be present for BPH to occur, but do not necessarily directly cause the condition. This is supported by the fact that castrated boys do not develop BPH when they age. On the other hand, administering exogenous testosterone is not associated with a significant increase in the risk of BPH symptoms. Dihydrotestosterone (DHT), a metabolite of testosterone, is a critical mediator of prostatic growth. DHT is synthesized in the prostate from circulating testosterone by the action of the enzyme 5alpha-reductase, type 2. This enzyme is localized principally in the stromal cells; hence, those cells are the main site for the synthesis of DHT. Investigations The following test are often performed in order to confirm a diagnosis: MSU USS Rule out cancer – PSA (cant really rule out but if <4 is less likely) Transrectal US +/- biopsy
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This note was uploaded on 12/04/2011 for the course ANTHRO 2000 taught by Professor Monicaoyola during the Fall '10 term at Broward College.

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Benign prostatic hyperplasia - Benign prostatic...

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