Blood6 - Blood Function composition components Clotting and...

Info iconThis preview shows pages 1–2. Sign up to view the full content.

View Full Document Right Arrow Icon
Blood – Function, composition, components. Clotting and Homeostasis Haemostasis Prevention of blood loss and clotting o Circulatory system will cease to function if blood is lost 4 stages that follow vascular injury o Vascular constriction o Platelet plugging/activation o Clot formation o Clot lysis/scar formation 4 Phases in Haemostasis Phase 1: Vascular spasm Following vascular trauma to a small artery or arteriole, the vessel may contract and perhaps even close the lumen This local and temporary effect is not fully understood but may involve o Neurogenic factors/pain receptors o Cessation in local production of NO (from NOS) and Prostacyclin (PGI2) o Mechanically damaged platelets Phase 2: The platelet plug Injury to the vessel wall exposes collagen and Von Willebrand factor (vWF) Platelets have receptors on their surface for collagen and vWF Binding to Collagen and vWF causes platelet activation and release of many activators o Thromboxane A2 Thromboxane A2 (TXA2), produced by activated platelets, has prothrombotic
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Image of page 2
This is the end of the preview. Sign up to access the rest of the document.

Page1 / 4

Blood6 - Blood Function composition components Clotting and...

This preview shows document pages 1 - 2. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online