Blood7 - • Primary site of synthesis is the Kidney(some...

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Blood – Function, composition, components. Calculating RBC Calculating the volume of a normal RBC (MCV) App. 4.8x10 12 RBC per L of Haematocrit blood Volume of a RBC in L =1/ 4.8x10 12 = 2.08x10 -13 or 208x10 -15 = 208fL However on 40% of blood volume is RBC’s Therefore volume of a RBC = 208fl x 40% = 83.2fl Volume of a RBC = (1/number of RBC’s per L) x % Haematocrit Calculating Mean Corpuscular Hb (MVH) of a normal RBC MVH = Hb/RBC Normal Hb = 12g/dL or 120g/L Normal RBC count = 4.8x10 12 /L MVH = 120/4.8x10 12 = 2.5x10 -11 = 25pg/RBC Mean Cell Haemoglobin Concentration in a normal RBC MCHC = Hb/Haematocrit MCHC = 12/0.4 = 30g/dL Erythropoietin (EPO) Erythropoietin (EPO)
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Unformatted text preview: • Primary site of synthesis is the Kidney (some in Liver) • 160aa protein that is N- and O-glycosylated • glycosylation is essential to function in vivo • Synthesis is stimulated by hypoxia/anaemia • Functions in combination with other hematopoietic growth factors (SCF, IL3) to stimulate erythropoiesis Clinical Significance of EPO • Over production of EPO produces polycythemia (over production of red cells) • secondary caused by high altitude training • Polycythemia Vera o Rare (mainly in men over 40 yrs) o 7-8million RBC/µl o Viscosity and potential clot formation increase risk of stroke and MI...
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This note was uploaded on 12/04/2011 for the course ANTHRO 2000 taught by Professor Monicaoyola during the Fall '10 term at Broward College.

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Blood7 - • Primary site of synthesis is the Kidney(some...

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