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Unformatted text preview: • Primary site of synthesis is the Kidney (some in Liver) • 160aa protein that is N- and O-glycosylated • glycosylation is essential to function in vivo • Synthesis is stimulated by hypoxia/anaemia • Functions in combination with other hematopoietic growth factors (SCF, IL3) to stimulate erythropoiesis Clinical Significance of EPO • Over production of EPO produces polycythemia (over production of red cells) • secondary caused by high altitude training • Polycythemia Vera o Rare (mainly in men over 40 yrs) o 7-8million RBC/µl o Viscosity and potential clot formation increase risk of stroke and MI...
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This note was uploaded on 12/04/2011 for the course ANTHRO 2000 taught by Professor Monicaoyola during the Fall '10 term at Broward College.
- Fall '10