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Unformatted text preview: Cardiovascular drugs ARBs ARBs lower BP by blocking angiotensin II (AT1) receptors causing vasodilation Similar properties to ACEI but do not cause cough (dont prevent bradykinin degeneration) All given orally od. Indications: Hypertension Prophylaxis for diabetic nephropathy (if ACEI not tolerated) Losartan ( Cozaar) Candesartan contraindicated in liver failure and cholestasis Irbesartan Olmesartan For all ARB's: Side effects : Hyperkalaemia (due to reduced aldosterone secretion) if taking K+ supplements/ on K+ sparing diuretics. Hypotension (as above) Contraindications: Breast feeding and Pregnancy Caution: RAS HOCM Mitral/aortic stenosis If taking drugs that increase potassium Caution in elderly Liver failure or renal failure. Interactions: NSAIDs reduce effects Diuretics increase risk of hypotension Increases effects of lithium Beta blockers All block B1 receptors to lower BP and prevent angina. Some also cause B2 blockade, which results in All block B1 receptors to lower BP and prevent angina....
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- Fall '10