Cardiovascular drugs Anti

Cardiovascular drugs Anti - Cardiovascular drugs...

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Cardiovascular drugs Anti-arrythmics These are used to treat cardiac arrhythmias Many can themselves induce lethal arrhythmias , particularly in patients with pre-existing ischaemic heart disease. Hence there has been an increase in the use of invasive devices and procedures as an alternative. Normally split into 4 classes: Class I – Act on Na+ channels IA – block open voltage-dependent Na+ channels to lengthen the AP. Quinidine, procainamide and disopyramide – used to treat recurrent ventricular arrhythmias. IB- block inactivated voltage-dependent Na+ channels. Ischaemic tissue has many inactivated channels. Therefore targets ischaemic tissue. Lidocaine post-MI ventricular arrhythmias and local anaesthetic. IC – dissociate very slowly from Na+ channels. Flecainide – prophylaxis for paroxysmal AF. Class II – Beta blockers – slow SAN/AVN conduction. Used to treat arrhythmias associated with stress and increased adrenergic activity – thyrotoxicosis, emotion, MI. See above for side
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This note was uploaded on 12/04/2011 for the course ANTHRO 2000 taught by Professor Monicaoyola during the Fall '10 term at Broward College.

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Cardiovascular drugs Anti - Cardiovascular drugs...

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