Cardiovascular drugs Calcium channel blockers

Cardiovascular drugs Calcium channel blockers -...

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Cardiovascular drugs Calcium channel blockers These bind to voltage dependent (L-type) calcium channels and block entry of calcium into cells . This causes relaxation of arteriolar smooth muscle , reducing peripheral resistance and therefore causing a fall in blood pressure . Diltiazem can be used to treat angina as cause a negative inotropic effect by reducing calcium influx during the plateau phase of the myocyte action potential. Verapamil is also a class IV antiarrhythmic Nifedipine, Felodipine, Amlodipine (dihydropyridines) – Used for angina prophylaxis, but have less effect on the heart than rate limiting types (only slightly increase heart rate and contractility) so used for hypertension. Nifedipine also used in treatment of Raynaud’s. Diltiazem (rate limiting type) – reduce heart rate and contractility. Most popular in treatment of angina as does not cause tachycardia Verapamil (rate limiting type) reduces heart rate and contractility - acts on AVN, used for prophylaxis of
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Cardiovascular drugs Calcium channel blockers -...

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