Cardiovascular drugs Inotropes

Cardiovascular drugs Inotropes - Cardiovascular drugs...

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Cardiovascular drugs Inotropes Inotropes are mainly used in heart failure Glycoside Digoxin increases force of contraction by block ing Na+K+ATPase. Competes with K+ ions so effects can be dangerously increased in hypokalaemia e.g. diuretics. Common Side Effects – nausea, vomiting, anorexia and diarrhoea. Digoxin toxicity: relatively common as therapeutic range is close to level at which arrhythmias can occur. Treat by stopping digoxin, K+ supplements, anti-arrhythmics (lidocaine) or digoxin specific ab fragments (used in very severe cases). Non-glycoside Dobutamine – Increase cAMP leading to increase in calcium channel opening. Given by IV infusion for severe, acute heart failure. Causes increased contraction and vasodilation (little effect on rate) Lipid lowering drugs Statins HMG CoA reductase inhibitors decrease hepatic cholesterol synthesis, reduce LDLS, slightly reduce trigylcerides. Used in
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Cardiovascular drugs Inotropes - Cardiovascular drugs...

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