Clot retraction - Clot retraction & repair: within...

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Clot retraction & repair: within 30-60 minutes after injury, platelets contract, pulling on fibrin strands to pull ends of torn vessel closer together Platelet-derived growth factor ( PDGF ) released by platelets to stimulate o Fibrinolysis : removes unneeded clots after healing has occurred Tissue plasminogen activator (tPA) activates plasma plasminogen , which is converted to plasmin Plasmin is an enzyme that digests fibrin, breaking down clot o Factors limiting clot growth/formation: Anticoagulants o Disorders of Hemostasis: Thromboembolytic disorders : a thrombus (clot) forms in an unbroken blood vessel; if it detaches from the vessel wall, the resulting embolus can travel warfarin o Bleeding disorders: thrombocytopenia
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Clot retraction - Clot retraction & repair: within...

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