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Contraction of Smooth Muscle

Contraction of Smooth Muscle - Regulation of Smooth Muscle...

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Contraction of Smooth Muscle: - uses sliding filament mechanism - no troponin or TnC. activate myosin o o activated calmodulin activates myosin light chain kinase o the activated kinase transfers phosphate from ATP to myosin cross bridges (heads) o phosphorylated myosin heads interact with actin of thin filaments - produces shortening of the muscle o intracellular calcium levels drop - relaxation
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Unformatted text preview: Regulation of Smooth Muscle Contraction:- can use similar mechanism to skeletal muscle. .. neurotransmitter release at neuromuscular junction generates action potential, which leads to rise in intracellular calcium- however, signal can be stimulatory or inhibitory for contraction- can use a variety of neurotransmitters (ACh, norepinephrine. ..), whereas skeletal muscle cells use ACh- smooth muscle cells can spontaneously depolarize in response to chemical stimuli Page5...
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