cyclic AMP signaling

cyclic AMP signaling - cyclic AMP signaling o the...

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cyclic AMP signaling: o the hormone ( first messenger ) binds the membrane receptor; the receptor changes shape, which allows it to bind G protein o o enzyme adenylate cyclase (GTP is hydrolyzed by GTPase activity of G protein) o activated adenylate cyclase converts ATP to cyclic AMP ( second messenger ); if inhibited, adenylate cyclase will not catalyze its reaction o cyclic AMP is free to circulate inside the cell; triggers activation of one to several protein kinase molecules; protein kinase phosphorylates (adds a phosphate group to) many proteins - the phosphorylated proteins may be activated or inhibited by phosphorylation - amplification effect: each activated adenylate cyclase can generate many cyclic AMP molecules; each protein kinase can catalyze hundreds of reactions - the end effect depends on the target cell (in thyroid cells, binding of TSH to its
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cyclic AMP signaling - cyclic AMP signaling o the...

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