Depression - Severe physical ill health Most endocrine,...

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Depression Causes Genetics Evidence suggests there is a genetic component backed up by twin and adoptive studies Psychosocial Depression heavily linked to traumatic life events such as: Loss of mother at a young age Unemployment and financial stress Lack of confiding relationships or breakdown of relationships Socio-economic deprivation Neurochemical Monoamine hypothesis Based on observations that in patients with depression the levels of Serotonin and Norepinephrine were lower than that of their non-depressed peers. Chronic stress theory Chronic stress leads to increased cortisol production. Increased cortisol decreases the expression of neurotrophins which are important in neuronal growth.
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Unformatted text preview: Severe physical ill health Most endocrine, many cancers and some viral infections have been linked with depression Some steroids, anti-hypertensives and oral contraceptive have been linked with depression Alcohol and alcoholism is a major source of depression Epidemiology Life time risk is about 10-20% Rates of depression in women are double that of men First onset is typically in third decade of life, with point prevalence higher in middle and old age. Depression is commoner in urban than rural areas, and particularly in women from lower SEC....
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Depression - Severe physical ill health Most endocrine,...

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