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Disorders of bleeding and thrombosi1

Disorders of bleeding and thrombosi1 - require treatment...

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Disorders of bleeding and thrombosis This notes covers disorders of bleeding and thrombosis Thrombocytopenia Thrombocytopenia is a failure of platelet production and can be caused by a number of reasons: 1. Pancytopenia (a deficiency of all blood cells) Aplastic anaemia Malignant infiltration B12 / folate deficiency 2. Decrease in megakaryocytes Drugs – tolbutamide Alcoholism Viruses – EBV, measles, varicella, CMV 3. Shortened half life 4. If megakaryocytes in marrow numerous, must have shortened life span 5. Commonly autoimmune thrombocytopenic purpura – This is idiopathic and can be acute (young) or chronic (older age group). It is know to cause, petechiae, bruising, spontaneous bleeding, thrombocytopenia and autoantibodies are present in the patients serum. Splenic destruction increased, often before the age of 10 following childhood viral infection. Patient often do not
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Unformatted text preview: require treatment but if they do can be treated with steroids, splenectomy or cytotoxics. 6. Secondary autoimmune thrombocytopenic purpura which can accompany SLE, lymphoma, leukaemia, HIV 7. Drug-induced immune thrombocytopenia which can follow the use of heparin, gold salts, quinine and penicillin. 8. Intravascular platelet consumption which can be caused by disseminated intravascular coagulation. 9. Increased pooling in large spleen - Normal spleen contains 30% of all platelet but in some cases it may contain up to 50 – 90% if enlarged. To treat thrombocytopenia you can perform a transfusion of platelets. This is performed in severe haemorrhage from thrombocytopenia, or abnormal platelet function and in those requiring massive blood transfusions....
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