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Unformatted text preview: proteases. Heparin prolongs APPT but can cause serious side-effects such as; thrombocytopenia, osteoporosis, alopecia and hypersensitivity. If an overdose is given, stop heparin, give protamine sulphate if severe, though heparin has short half life anyway. Warfarin This is a vitamin K antagonist and inhibits production / activation of vitamin K-dependant factors (II, VII, IX and X). Warfarin Prolongs PT (and INR) but has many drug interactions: • Decrease intestinal absorption of vitamin K (antibiotics, laxatives) • Reduce warfarin binding to albumin (phenylbutazone) • Inhibit hepatic degradation (cimetidine) • Side-effects: Teratogenic. • Overdose / over anticoagulation:Stop warfarin, give fresh-frozen plasma and / or vitamin K...
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This note was uploaded on 12/04/2011 for the course ANTHRO 2000 taught by Professor Monicaoyola during the Fall '10 term at Broward College.
- Fall '10