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Unformatted text preview: • X-linked • Clinically indistinguishable from haemophilia A • Normal PT, prolonged APTT • Treat by replacing factor IX Von Willebrand’s disease • Usually autosomal dominant • Prolonged APTT, normal PT • Desmopressin can be used to increase factor VIII and VWF • Otherwise, Factor VIII and VWF concentrates are given Acquired coagulation disorders • Hepatocytes synthesise all coagulation factors other than factor VIII. • Liver disease results in decreased factor synthesis, and reduced clearance of activated factors and t-PA. • Disseminated intravascular coagulation / increased fibrinolysis. • Coumarin’s (Warfarin) inhibit vitamin K-dependant enzyme. • Factors produced by this enzyme (II, VII, IX and X) less biologically active. • Same observed in neonates, and individuals deficient in vitamin K....
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This note was uploaded on 12/04/2011 for the course ANTHRO 2000 taught by Professor Monicaoyola during the Fall '10 term at Broward College.
- Fall '10