Endocrine drugs Thyroid drugs

Endocrine drugs Thyroid drugs - Endocrine drugs Thyroid...

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Endocrine drugs Thyroid drugs Anti-thyroid drugs: Carbimazole Thionamide. Peroxidase inhibitor, which stops conversion of iodide to iodine. ?Immunosuppressant effect. Dose/route: 15-60mg/day divided into BD/TDS PO. Can reduce dose once euthyroid (usually only give for 12-18 months then think radioiodine or surgery) Side Effects: Rash and pruritis due to hypersensitivity – switch to propyluracil , agranulocytosis – warn pt to see Dr if repeated sore throat, fever, mouth ulcers etc. Propylthiouracil Thionamide. Peroxidase inhibitor but lso reduces peripheral conversion of T4 to T3. Second line rx for hyperthyroidism if carbimazole not tolerated. ?Immunosuppressant effect. Dose/route: 200-400mg OD PO until euthyroid then reduce to 50-150mg OD. Side Effects: agranulocytosis (warn and monitor FBC and clotting) and skin reactions Thyroid replacement therapy: Levothyroxine Synthetic T4
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Dose/route: 25-200 micrograms mane PO Side Effects: Features of hyperthyroidism – should be minimal, osteoporosis Contraindications:
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