Endocrine drugs - Endocrine drugs This is a short guide to...

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Endocrine drugs This is a short guide to drugs used to treat endocrine problems. The information outlined applies to UK guidelines and is meant as a guide only. Please consult your local guidelines before treating any patients. Diabetes drugs In diabetes there is a relative or total lack of insulin, which reduces glucose uptake by insulin-sensitive tissues. This Results in… Hyperglycaemia – leading to glycosuria causing polyuria and polydipsia Lipolysis – leading to increased FFAs resulting in ketonaemia, acidosis, coma and death. Biguanides - Metformin Works by 3 mechanisms: Reduces hepatic gluconeogenesis Reduces glucose absorption in GIT Increases insulin sensitivity (+) Weight neutral, no hypo's, cheap. Dose/route: Initially 500mg mane (max 3g/day) usually divided into 2 or 3 doses, with food. Oral. Side Effects: GI upset , metallic taste, headache, lactic acidosis. Contraindications:
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Endocrine drugs - Endocrine drugs This is a short guide to...

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