GI drugs Laxatives

GI drugs Laxatives - GI drugs Laxatives Bulk laxatives...

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GI drugs Laxatives Bulk laxatives – increase volume of intestinal content, stimulating peristalsis by activating stretch receptors. Indigestible polysaccharides such as cellulose (bran). Osmotic laxatives – increase bulk in bowel by retaining water by osmotic effect. Include salts containing poorly absorbed ions such as MgSO4 and lactulose . Lactulose – also used for hepatic encephalopathy Dose/route: 15ml od/bd (depending on response) can take two days to work. Side Effects: Flatulence, distension and abdo pain Contraindications: GI obstruction, galactosaemia Stimulant laxatives – increase motility by acting on mucosa or nerve plexuses. Can cause abdominal cramp. Senna acts on the myenteric plexus. Senna – takes 8-12hrs to work Dose/route – 2 tablets nocte or available as syrup. Side Effects: Abdominal cramps, with prolonged use can develop atonic colon and hypokalaemia Contraindications: Obstruction, caution in pregnancy (try above first) Faecal softeners – promote defecation by softening stools or by lubricating faeces. Liquid paraffin
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This note was uploaded on 12/04/2011 for the course ANTHRO 2000 taught by Professor Monicaoyola during the Fall '10 term at Broward College.

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GI drugs Laxatives - GI drugs Laxatives Bulk laxatives...

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