GI drugs - GI drugs This article is an overview of drugs...

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GI drugs This article is an overview of drugs that can be used to treat disorders and diseases of the gastrointestinal system. These treatment regimes are based on UK guidelines. For more information about other regimes consult you local hospital trust. Drugs affecting acid secretion Proton pump inhibitors Inhibit H+/K+ ATPase of parietal cells to reduce acid secretion Used to treat PUD, GORD, H.pylori infection and Zollinger-Ellison syndrome. Omeprazole – 20mg OD PO (BD in triple therapy). IV infusion for acute GI bleed. Side Effects: GI upset, headache , dizziness, arthralgia. Rarely hepatotoxic. Caution: can mask symptoms of gastric cancer Interactions: Affect P450 so increase effects of phenytoin, diltiazem and digoxin. Mildly increase effects of warfarin. Lanzoprazole – 15-30mg OD PO. As omeprazole but less interactions. Histamine H2 receptor antagonists Block action of histamine on parietal cells to reduce acid secretion. Relieve pain of peptic ulcer and increase healing. Also used to treat GORD.
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This note was uploaded on 12/04/2011 for the course ANTHRO 2000 taught by Professor Monicaoyola during the Fall '10 term at Broward College.

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GI drugs - GI drugs This article is an overview of drugs...

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