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Unformatted text preview: be given in high doses initially for at least two weeks. Whilst indomethacin has historically been the most commonly used NSAID, an alternative, such as ibuprofen, may be preferred due to its better side effect profile in the absence of superior effectiveness. For individuals who are unable to take NSAIDs, i.e. those with renal failure or peptic ulcers, they may be co-prescribed a Proton Pump Inhibitor or Colchicine. Colchicine is an alternative for those unable to tolerate NSAIDs. Colchicine is a toxic natural product and secondary metabolite, originally extracted from plants. Its side effects (primarily gastrointestinal upset) limit its usage. Gastrointestinal upset, however, depends on the dose, and the risk can be decreased by using smaller yet still effective doses....
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- Fall '10