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Gout2 - from the body through the bowel and kidney Renal...

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Gout Gout is a Crystalopathy caused by excess accumulation of monosodium urate crystals in the body tissues and joints Symptoms Gout can present in a number of ways, although the most usual presentation is:- A recurrent monoarhrotpathy where the joint becomes o Red (Rubor) o Hot (Calor) o Tender (Dolor) o Swollen (Tumor) Common sites include:- o 1 st metatarsal joint o Calcaneal joint o Knees o Carpal joints o Joints of the hands The joint pain usually comes on over 2-4 hours over night. Other systemic symptoms include fever, fatigue, malaise and trophi found on the ear. Important differentials include septic arthritis, caused by infection, pseudo gout, caused by calcium pyrophosphate and early rheumatoid arthritis. Causes Hyperuricemia is the underlying cause of gout. This can occur for a number of reasons, including diet, genetic predisposition, or under excretion of urate, the salts of uric acid. Uric acid is normally secreted
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Unformatted text preview: from the body through the bowel and kidney. Renal under excretion of uric acid is the primary cause of Hyperuricemia in about 90% of cases, while overproduction is the cause in less than 10%. Risk factors for Gout include:-• Lifestyle o Excess alcohol intake o Excess fructose sweetened drinks o A diet rich in meats, cheeses and seafood • Genetics o Family history of Gout o A few rare genetic causes predispose people, these include:- Familial Juvenile Hyperuricemic Nephropathy Medullary Cystic Kidney Disease Phosphoribosylpyrophosphate Synthetase Super activity • Medical conditions o Metabolic syndrome o Obesity o Hypertension o Renal failure • Medications o Diuretics o Niacin o Aspirin o Cyclosporin...
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