Haemochromotosis Diagnosis

Haemochromotosis Diagnosis - acute patients. In patients...

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Haemochromotosis Diagnosis With a family history of haemochromatosis and/or presenting symptoms suggestive of impotence, diabetes, or bronzening of the skin, the first test to order should be fasting serum transferrin saturations. This will likely be increased to >45% in haemochromatosis. Other tests to order = serum ferritin level (usually > than 675 picomoles/L) but may also be raised in alcoholism, serum iron levels (>30 µmol/L), TFTs, Lipid Profile, ECG, and Liver Biopsy (gold standard) for raised iron content Women are more likely to present later in life than men due to the protective effect of iron loss during menses and pregnancy. Treatment The main goal of treatment for haemochromatosis is to avoid iron overload. Other lifestyle changes should include: avoiding alcohol, reducing Vitamin C and keeping up-to-date with hepatitis vaccinations. Treatment should consist of a monitoring regimen of transferritin and iron levels every 1-3 years in sub-
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Unformatted text preview: acute patients. In patients with clinical symptoms, patients should be started on a phlebotomy regimen. This would involve weekly phlebotomy sessions to reduce serum ferritin level to ≤120 picomol/L. This should be continued over time to maintain serum iron below this level. If phlebotomy is contraindicated (e.g. severe anaemia, heart disease), patients should be treated with oral iron-chelating agents such as deferasirox (0-30 mg/kg/day). Prognosis Treatment returns life expectancy to normal if patient non cirrhotic and no diabetic Joint problems may / may not improve Hypogonadism irreversible > 10% of cirrhotic patients will develop Increased risk of hepatocellular carcinoma Prevention Patients should be advised by their family physician and spet to avoid additional supplementation of iron and vitamin C....
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This note was uploaded on 12/04/2011 for the course ANTHRO 2000 taught by Professor Monicaoyola during the Fall '10 term at Broward College.

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Haemochromotosis Diagnosis - acute patients. In patients...

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