Unformatted text preview: Upon reactivation, the virus replicates in the nerve cells, and virions are shed from the cells and carried down the axons to the area of skin served by that ganglion. In the skin, the virus causes local inflammation and blisters. As with chickenpox and/or other forms of herpes, direct contact with an active rash can spread VZV to a person who has no immunity to the virus. This newly infected individual may then develop chickenpox, but will not immediately develop shingles. Epidemiology The incidence rate of herpes zoster ranges from 1.2 to 3.4 per 1,000 person-years among healthy individuals, increasing to 3.9–11.8 per 1,000 person ‐ years among those older than 65 years. Herpes zoster affects both genders equally and may develop in any age group, but its incidence is increased in those • Older than 60 • Who had chickenpox before age 1 • Whose immune system is weakened by medications or disease...
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- Fall '10
- Anthropology, Chickenpox, Herpesviridae, Herpes simplex virus, Herpes zoster, Varicella zoster virus