How the immune system functions Antibodies

How the immune system functions Antibodies - How the immune...

Info iconThis preview shows pages 1–2. Sign up to view the full content.

View Full Document Right Arrow Icon
How the immune system functions Antibodies Antibody is secreted by the plasma cell (CD38, CD138) which is the end cell of differentiation of B lymphocytes It is a multi-functional protein with o antigen binding properties o immune effector functions These are performed by different parts of the molecule and so it is important to understand the structure There are 5 types: M, G (several subtypes), A, D (unimportant) and E These differ in o molecular structure o stage of the immune response in which they are produced o function The 4 secreted types can be produced by the same B cell in succession These different types produced by the same B cell all have the same antigen binding region but different effector Fc regions M is produced first: the others later
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
The amounts of the different antibodies produced during an infection depend on cytokines: IL-4 increases Ig production globally and favours a shift to IgE This depends on the type of help given to the B cell during its activation
Background image of page 2
This is the end of the preview. Sign up to access the rest of the document.

Page1 / 2

How the immune system functions Antibodies - How the immune...

This preview shows document pages 1 - 2. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online