How the immune system functions Complement

How the immune system functions Complement - How the immune...

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How the immune system functions Complement A complex mixture of serum proteins Detailed knowledge of biochemistry unimportant When activated in infection, complement components have a number of important immunological effector functions There are 2 mechanisms for its activation: o Interaction with Fc region of an antibody-antigen complex (IgM & G): “classical pathway”; o Interaction with microbial cell surface structures e.g. LPS, certain polysaccharides: “alternative pathway”. o Details of activation pathways are not important Components of activated complement are o Chemo attractants and activators of neutrophils “anaphylotoxins” o Activators of endothelial cells; o Opsonins (myeloid cells bear complement receptors) o They also form the “membrane attack complex” which can lyse cells Phagocytosis This is an essential mechanism for eliminating bacteria, other particles and complexes between antigens and antibodies The engulfed material is destroyed by oxidative mechanisms
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This note was uploaded on 12/04/2011 for the course ANTHRO 2000 taught by Professor Monicaoyola during the Fall '10 term at Broward College.

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How the immune system functions Complement - How the immune...

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