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Huntingto1 - progression of symptoms A longer repeat...

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Huntington's Disease Epidemiology The late onset of Huntington's disease means it doesn't affect reproduction, allowing the faulty genes to be passed on unknowingly. It has a worldwide incidence of approximately 5-10 per 100,000, but varies greatly geographically as a result of ethnicity, local migration and past immigration patterns. Incidence is highest in populations of Western European decent and incidence is lowest in Asian and African cultures – roughly affecting 1 in 1,000,000. It affects men and women equally. Prognosis The length of the trinucleotide repeat accounts for 60% of the variation in the age of onset and the rate of
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Unformatted text preview: progression of symptoms. A longer repeat results in an earlier age of onset and a faster progression of symptoms. The average time of survival from the time of diagnosis is 16-20 years. Many patients die from pneumonia caused by aspiration of food and drink. Suicide is the next greatest causes of fatalities, with 7.3% of those with Huntington's taking their own lives and up to 27% attempting to do so. Prevention Inheritance of faulty genes can be prevented through IVF if there is a known family history of Huntington's disease, however in de-novo mutations it cannot be prevented....
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