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Unformatted text preview: Huntington's Disease Huntington's Disease is a rare hereditary neurodegenerative disorder that affects muscle coordination and leads to cognitive decline and dementia. It typically becomes noticeable in middle age. Symptoms Symptoms of the disease usually start in early middle age and include:- • Disturbance of movement Involuntary jerky movement (chorea) affect 90% of patients Loss of muscle tone or increased rigidity Difficulties maintaining posture and movement Dysarthria (inability to pronounce words) Dysphagia (difficulty swallowing) Abnormal eye movements • Progressive deterioration of mental function leading to dementia Impaired intellectual ability Loss of concentration Loss of short and long term memory Loss of problem solving ability Personality changes Depression Psychosis In the early stages, there are subtle changes in personality, cognition and physical skills. The physical symptoms are usually the first to be noticed, as cognitive and psychiatric symptoms are generally not...
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- Fall '10
- Anthropology, trinucleotide repeat, Htt protein interacts, hereditary neurodegenerative disorder