This preview has intentionally blurred sections. Sign up to view the full version.View Full Document
Unformatted text preview: Early T cell precursors derived from CLPs migrate to the thymus where they complete their maturation and then enter the periphery as CD4 or CD8 cells • A key step in the differentiation of B & T lymphocytes is development of their antigen receptors sIg and TCR • CMPs give rise to either o megakaryocyte (generates platelets)/erythrocyte o granulocyte/macrophage progenitors • These latter differentiate within the bone marrow to give rise to all the myeloid cells What drives haematopoiesis? • A range of cytokines and growth factors which bind to specific receptors on the developing cells. • These are generated o by the stromal cells of the primary lymphoid tissues, & may be cell-surface expressed (juxtacrine); o or (especially during infection/inflammation) by activated leukocytes in other tissues (paracrine) (e.g. IL-6) Simplified haematopoiesis scheme...
View Full Document
- Fall '10
- Anthropology, cells, Bone marrow, Progenitor Cells, lymphoid progenitor cells