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Unformatted text preview: Early T cell precursors derived from CLPs migrate to the thymus where they complete their maturation and then enter the periphery as CD4 or CD8 cells A key step in the differentiation of B & T lymphocytes is development of their antigen receptors sIg and TCR CMPs give rise to either o megakaryocyte (generates platelets)/erythrocyte o granulocyte/macrophage progenitors These latter differentiate within the bone marrow to give rise to all the myeloid cells What drives haematopoiesis? A range of cytokines and growth factors which bind to specific receptors on the developing cells. These are generated o by the stromal cells of the primary lymphoid tissues, & may be cell-surface expressed (juxtacrine); o or (especially during infection/inflammation) by activated leukocytes in other tissues (paracrine) (e.g. IL-6) Simplified haematopoiesis scheme...
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This note was uploaded on 12/04/2011 for the course ANTHRO 2000 taught by Professor Monicaoyola during the Fall '10 term at Broward College.
- Fall '10