Immunodeficiency and malignancies Complement deficiencies

Immunodeficiency and malignancies Complement deficiencies -...

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Unformatted text preview: Immunodeficiency and malignancies Complement deficiencies Complement deficiencies affect either the classical pathway or the alternate pathway o Classical pathway activated by Antigen-Antibody complexes o Alternate pathway EITHER activated by bacterial mannans via mannan binding lectin (MBL) OR by other cell surface components binding complement They are due to lack of one of the many components of the complement system Nearly all are due to genetic defects Infections, due to failure of Antibody-mediated complement lysis of bacteria (etc), especially: o Streptococcus pneumoniae, Neisseria meningitides and N. gonorrhoea o Immune complex diseases because of failure to clear Ag:Ab complexes o Systemic lupus erythematosis (SLE) o Glomerulonephritis Diagnostic tests o Complement function o Absence of specific components Classical haemolytic 50 (CH50) measures the activity of the classical pathway Titrate serum: determine concentration to lyse 50% of red blood cells coated with antibody...
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This note was uploaded on 12/04/2011 for the course ANTHRO 2000 taught by Professor Monicaoyola during the Fall '10 term at Broward College.

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Immunodeficiency and malignancies Complement deficiencies -...

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