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Immunodeficiency and malignancies Complement deficiencies

Immunodeficiency and malignancies Complement deficiencies -...

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Unformatted text preview: Immunodeficiency and malignancies Complement deficiencies • Complement deficiencies affect either the “classical” pathway or the “alternate” pathway o Classical pathway activated by Antigen-Antibody complexes o Alternate pathway EITHER activated by bacterial mannans via mannan binding lectin (MBL) OR by other cell surface components binding complement • They are due to lack of one of the many components of the complement system • Nearly all are due to genetic defects • Infections, due to failure of Antibody-mediated complement lysis of bacteria (etc), especially: o Streptococcus pneumoniae, Neisseria meningitides and N. gonorrhoea o Immune complex diseases because of failure to clear Ag:Ab complexes o Systemic lupus erythematosis (SLE) o Glomerulonephritis • Diagnostic tests o Complement function o Absence of specific components • Classical haemolytic 50 (CH50) measures the activity of the classical pathway • Titrate serum: determine concentration to lyse 50% of red blood cells coated with antibody...
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