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Immunodeficiency and malignancies Haematopoietic malignancies

Immunodeficiency and malignancies Haematopoietic malignancies

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Immunodeficiency and malignancies Haematopoietic malignancies These are a very diverse group of diseases affecting the immune system o Underlying defect is uncontrolled proliferation of a lymphoid or myeloid precursor OR a more mature cell including plasma cells o Never the CD34 stem cell o Lead to defects in the immune system (but this is usually not the patient’s main problem) Nomenclature: conventionally divided into o Leukaemia Cells proliferate in the marrow & spill over into the circulation (hence leuk | aemia); o Lymphoma Cells proliferate in lymph nodes which swell (hence lymphoma), not present in circulation o Myeloma Cells proliferate in bone marrow (myel | oma), not present in circulation. Nomenclature: then named for the specific cell type involved: o E.g. B cell lymphoma (many different kinds), affecting mature B cells; o E.g. Acute myeloid (myelogenous) leukaemia (AML) affecting pre-granulocyte/monocyte cells. Acute leukaemias & high grade lymphomas develop rapidly;
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