Immunodeficiency and malignancies Immunoglobulin deficiency

Immunodeficiency and malignancies Immunoglobulin deficiency...

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Immunodeficiency and malignancies Immunoglobulin deficiency Immunoglobulin Deficiency (B-cell knocked out) Presents with upper and lower respiratory infections (etc) Often not considered until many infections and organ damage (e.g. bronchiectasis, deafness) Simple test – measure immunoglobulin levels o Take account of patient’s age: neonates have only IgG (from mother) & blood concentrations decline over first 1-2 months; o Then rise to adult levels over years Primary Immunoglobulin deficiency Examples: Primary Bruton’s X-linked α gammaglobinaemia Common variable immunodeficiency (aka non-familial hypogammaglobinaemia) Subclass deficiency Secondary Protein loss (e.g. nephrotic syndrome) Some cancers Drugs (cancer chemotherapy, anti-rheumatic) Bruton’s a-gammaglobinaemia aka X-linked alpha gammaglobinaemia (XLA) Xq21.3, locus for a tyrosine kinase needed for pre-B cell proliferation; Infant boys ----- adults, variable severity; No B cells (CD19 sig), so no Ig;
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This note was uploaded on 12/04/2011 for the course ANTHRO 2000 taught by Professor Monicaoyola during the Fall '10 term at Broward College.

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Immunodeficiency and malignancies Immunoglobulin deficiency...

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