{[ promptMessage ]}

Bookmark it

{[ promptMessage ]}

Immunodeficiency and malignancies T

Immunodeficiency and malignancies T - o Failure to thrive o...

Info iconThis preview shows pages 1–2. Sign up to view the full content.

View Full Document Right Arrow Icon
Immunodeficiency and malignancies T-cell deficiencies Primary Severe combined immunodeficiency - SCID DiGeorge syndrome Secondary HIV infection Iatrogenic (e.g. anti-T cell Ab therapy) Severe combined immunodeficiency Failure of T (+/- B / NK) cell development and so defects in all branches of immunity Genetic: due to mutations in one of about a dozen genes Different cellular profiles: T-B+NK-, T-B-NK-, T-B-NK+, and T-B+NK+ depending on exact genetic defect Note that it is combined immunodeficiency meaning failure of all parts of the adaptive immune response This occurs even where the only cellular defect is in T cells This emphasises the key central role of T cells for ALL adaptive immunity through providing HELP for activation of other cells Presents within first months of life o Recurrent infections (bacteria, viruses, fungi)
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Background image of page 2
This is the end of the preview. Sign up to access the rest of the document.

Unformatted text preview: o Failure to thrive o Unusual rashes, diarrhoea o Fatal if untreated • Suspect in any neonate or infant with failure to thrive, infections, recurrent hospital admissions • Diagnosis: o Test for presence and normal function of T cells SCID – Treatment • Suspect and then protect: o Isolate - barrier nursing o Prophylactic antibiotics o No live vaccines o Blood products CMV-negative, irradiated • Bone marrow / stem cell transplantation. • Gene therapy o about 20 done: leukaemia a complication Di George • Most are congenital: due to a deletion in chromosome 21 o A developmental problem leading to thymic hypoplasia so few T cells • A similar syndrome may be associated with foetal alcohol syndrome Secondary T cell Immunodeficiency’s • AIDS • Transplantation immunosuppression...
View Full Document

{[ snackBarMessage ]}

Page1 / 2

Immunodeficiency and malignancies T - o Failure to thrive o...

This preview shows document pages 1 - 2. Sign up to view the full document.

View Full Document Right Arrow Icon bookmark
Ask a homework question - tutors are online