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Unformatted text preview: o Failure to thrive o Unusual rashes, diarrhoea o Fatal if untreated • Suspect in any neonate or infant with failure to thrive, infections, recurrent hospital admissions • Diagnosis: o Test for presence and normal function of T cells SCID – Treatment • Suspect and then protect: o Isolate - barrier nursing o Prophylactic antibiotics o No live vaccines o Blood products CMV-negative, irradiated • Bone marrow / stem cell transplantation. • Gene therapy o about 20 done: leukaemia a complication Di George • Most are congenital: due to a deletion in chromosome 21 o A developmental problem leading to thymic hypoplasia so few T cells • A similar syndrome may be associated with foetal alcohol syndrome Secondary T cell Immunodeficiency’s • AIDS • Transplantation immunosuppression...
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- Fall '10
- Anthropology, severe combined immunodeficiency, malignancies T-cell deficiencies, e.g. anti-T cell, Different cellular profiles, recurrent hospital admissions