Immunodeficiency and malignancies

Immunodeficiency and malignancies - Immunodeficiency and...

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Immunodeficiency 1. Primary Immunodeficiency: 1. No known extrinsic cause 2. May be inherited 3. Manifested either in infant or later 2. Secondary Immunodeficiency: 1. Due to a known extrinsic cause 2. e.g. HIV, Iatrogenic, Burns, Splenectomy The first described primary immunodeficiency 1952 - Ogden C Bruton described a boy with recurrent bacterial infections and absent Immunoglobulins in serum Boys without B cells: o Bruton’s X-linked α gammaglobulinaemia Lots of different ones – at least 120 primaries plus many secondary’s o Primary immunodeficiency is not uncommon: o All primary immunodeficiency ≈ 1:10,000 Severe combined immunodeficiency (SCID) > 1:100,000 Compare cystic fibrosis at 1:2,500 the commonest inherited disease And secondary: o AIDS: about 60,000 (1:1000) living with HIV in UK who would become immunodeficient without antiviral treatment o Transplant patients: all immunosuppressed o Other drugs: e.g. Cancer chemotherapy
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This note was uploaded on 12/04/2011 for the course ANTHRO 2000 taught by Professor Monicaoyola during the Fall '10 term at Broward College.

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Immunodeficiency and malignancies - Immunodeficiency and...

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