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Infections of the nervous system

Infections of the nervous system - Infections of the...

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Infections of the nervous system Typical CSF profiles in Meningitis Normal Acute Pyogenic (Bacterial) Viral Appearance of CSF Clear Purulent Clear/Turbid Cell content (mm 3 ) 0-4 Leucocytes Polymorph Leucocytes Lymphocytosis Protein (mg/dl) 15-45 raised raised Glucose (mg/dl) 50-80 lowered Normal or slightly lowered Bacteriology Sterile Causative Organisms Usually negative Encephalitis Encephalitis/Myelitis: Diffuse inflammatory process of parenchyma of brain &/or spinal cord Leads to neuronal swelling & death Caused by: Viruses (e.g. Herpes simplex, Polio & Rabies; Rickettsiae), certain bacterial organisms (e.g. Listeria, Treponema & Borrelia) Meningo-encephalitis: Simultaneous diffuse inflammation of brain & meninges; Due to any of organisms mentioned Cerebral Abscess Focal infection of brain parenchyma due to wide range of bacteria & fungi May occur: Secondary to meningitis; Haematological spreads from distant focus of infection; Local extension of sepsis by direct spread or process of thrombophlebitis
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