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Kidney Physiology - Kidney Physiology Mechanisms of Urine...

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Kidney Physiology: Mechanisms of Urine Formation - ~1000-2000 ml blood pass through glomeruli each minute; ~650 ml of this is plasma; ~120-125 ml of plasma is forced into renal tubules - filtrate : everything in blood plasma except proteins - urine : mostly metabolic wastes & unneeded substances (filtrate without most water, nutrients & essential ions) - Glomerular filtration : mostly a passive, nonselective process in which fluids & solutes are forced through a membrane by hydrostatic pressure o glomerulus is a much more efficient filter than tissue capillary beds because: filtration membrane is thousands of times more permeable to water than other capillary membranes glomerular blood pressure is much higher than other capillary beds (~55 mm Hg vs. ~18 mm Hg), resulting in a much higher net filtration pressure o Net filtration pressure (NFP) : NFP = Hp g – (Op g + Hp c ) normally ~ 10 mm Hg glomerular hydrostatic pressure (Hp g ): chief force pushing water & solutes out of blood across filtration membrane; normally ~ 55 mm Hg
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