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Ovarian cance1 - Interestingly there is a 50 decrease in...

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Ovarian cancer Ovarian cancer is malignant transformation of the ovarian capsule epithelium and tissue. Symptoms Signs and symptoms of ovarian cancer are frequently absent early on and when they exist they may be subtle. In most cases, the symptoms persist for several months before being recognized and diagnosed. Non-specific gastrointestinal symptoms, such as bloating, nausea and vomiting, dyspepsia, early satiety, diarrhoea and/or constipation. These are usually present for >3 months. Ascites may be present. Palpable adnexal mass on physical examination. Usually late presentation Causes Latest data has reported the link of ovarian cancer with BRCA1 (tumour suppressor gene involved in DNA repair) and BRCA 2. There is a strong Family History link with ovarian cancer and breast cancer.
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Unformatted text preview: Interestingly, there is a 50% decrease in ovarian cancer risk with 5 years or more years of use of Oral Contraceptive Pill. Epidemiology UK = 6900 new cases per year; 4600 deaths from the disease each year. The median age of ovarian cancer = 60 years old Diagnosis Diagnosis of ovarian cancer starts with a physical examination (including a pelvic examination), a blood test (for CA-125 and sometimes other markers), and transvaginal ultrasound. The diagnosis must be confirmed with surgery to inspect the abdominal cavity, take biopsies (tissue samples for microscopic analysis) and look for cancer cells in the abdominal fluid: • Pelvic ultrasound (look for ovarian mass) • Pelvic/Abdominal CT (look for metastasis) • CA-125 tumour marker (>35 units/mL = probable cancer)...
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