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Unformatted text preview: conditions. A definitive diagnosis can be made from the following investigations:- Blood tests o Specifically from raised Alkaline Phosphatase with normal calcium and phosphate. This profile indicated raised bone turnover X-rays o Features on X-ray vary from predominantly lytic lesions, through a mixed phase, to a mainly sclerotic phase of bone expansion o Typically loss of distinction between the cortex and trabeculae is observed due to thickening of the trabecular bone Isotope Bone Scans o These highlight the degree of skeletal involvement but are unable to distinguish between Pagets disease and metastatic bone deposits (which typically are derived from breast and prostate malignancies)...
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- Fall '10