Paget - conditions A definitive diagnosis can be made from...

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Paget’s Disease Epidemiology The highest prevalence of Paget’s disease is likely to be in the UK where 3.6% of the population over 40 years of age and 5.4% of the population over the age of 55 are affected to some degree. Epidemiological studies are difficult as most individuals with Paget’s disease are asymptomatic and not affected by the condition. It is believed Paget’s affects men more so than women with a ratio of 3:2. Below the age of 40 it is rarely seen. A positive family history is observed in approximately 15% of cases. Diagnosis Diagnosis of Paget’s is usually inferred from a history of bone pain coupled with deformity. Initially Paget’s may be misdiagnosed as Osteoarthritis, in part due to its higher prevalence but also due to a similar set of symptoms. Many mild cases go undiagnosed or are only picked up during investigation for other
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Unformatted text preview: conditions. A definitive diagnosis can be made from the following investigations:-• Blood tests o Specifically from raised Alkaline Phosphatase with normal calcium and phosphate. This profile indicated raised bone turnover • X-rays o Features on X-ray vary from predominantly lytic lesions, through a mixed phase, to a mainly sclerotic phase of bone expansion o Typically loss of distinction between the cortex and trabeculae is observed due to thickening of the trabecular bone • Isotope Bone Scans o These highlight the degree of skeletal involvement but are unable to distinguish between Paget’s disease and metastatic bone deposits (which typically are derived from breast and prostate malignancies)...
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