Paget1 - Weekly and monthly preparations are also available...

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Paget’s Disease Treatment Currently there is no cure for Paget’s disease. Classically the mainstay of therapy was pain alleviation with simple analgesics (paracetamol ± codeine) or NSAIDs (Ibuprofen, Diclofenac etc.) and joint replacement surgery to correct joint disease. The advent of Bisphosphonates, drugs which inhibit bone resorption through action mainly directed as osteoclasts, has provided further therapeutic scope for patients with severe disease. Bisphosphonates can be given orally or via IV preparations. Oral bisphosphonates are typically given at a higher dose that those for osteoporosis. Options include:- Tiludronate – 400mg daily for 12 weeks repeated as necessary after 6 weeks or longer Ibandronate – 30mg daily for 2 months, repeated if necessary after at least 2 months Risedronate – 30mg daily for 2 months, repeated as necessary after at least 2 months Alendronate – 10-40mg daily for 6 months, repeated as necessary after at least 6 months
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Unformatted text preview: Weekly and monthly preparations are also available which help reduce medication side effects and the number of tablets taken on a daily basis. Surgery is still sometimes needed to replace joints or remove resistant and painful areas of bone. Intra-articular injections can be useful to differentiate between bone and joint disease. In cases of osteosarcoma amputation is typically required to prevent spread. Prognosis If diagnosed early and the appropriate treatment steps are put in place many patients enjoy a symptomless normal adult life. The most serious complication is the development osteosarcoma (less that 1% of cases) which typically has a poor prognosis in regards to bone salvation, many patients with osteosarcoma die within 12 months of diagnosis. Prevention There is no means of preventing the onset of Paget’s disease; however the symptoms can be controlled with good medication compliance....
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Paget1 - Weekly and monthly preparations are also available...

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