Physiological effects of pregnancy Metabolic

Physiological effects of pregnancy Metabolic -...

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Physiological effects of pregnancy Metabolic Diabetes: Pregnancy is Diabetogenic Diabetes mellitus affects all systems in the body-actual or effective insulin deficiency Incidence of 3-4 per 1000 pregnancies Foetus has little capacity for gluconeogenesis. Therefore glucose obtained from maternal blood Maternal endocrine controls designed to keep blood glucose levels within tight limits o Insulin secretion prevents hyperglycaemia by increasing glucose utilisation for glycogen and fat synthesis and storage o Gut absorption and gluconeogenesis prevent hypoglycaemia Progesterone increases maternal appetite and stimulates deposition of glucose in fat stores o Also increases renal gluconeogenesis o Increased protein catabolism Human placental lactogen (hPL, hPS) acts like growth hormone (GH) o Mobilises fatty acids for maternal metabolism Relative insulin insensitivity in later pregnancy o Reduced insulin sensitivity also due to effects of increased levels of cortisol, oestrogen
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Physiological effects of pregnancy Metabolic -...

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