Physiology of the Autonomic Nervous System

Physiology of the Autonomic Nervous System - Physiology of...

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Physiology of the Autonomic Nervous System Neurotransmitters & Receptors - acetyl choline & norepinephrine (noradrenaline) are the major neurotransmitters released by ANS neurons - cholinergic fibers: release acetyl choline (all parasympathetic postganglionic axons & sympathetic postganglionic axons innervating sweat glands & some blood vessels) cholinergic receptors: o nicotinic receptors: found on all ganglionic neurons (both sympathetic & parasympathetic) & adrenal medulla; response is always stimulatory o muscarinic receptors : found on all parasympathetic target organs & some sympathetic targets (eccrine sweat glands & some blood vessels); response may be stimulatory or inhibitory acetyl choline is quickly inactivated in a synapse by acetylcholinesterase (AChE) - adrenergic fibers: release norepinephrine (most sympathetic postganglionic axons) adrenergic receptors: alpha receptors & beta receptors o -1 & -1 receptors (response is generally stimulatory) o -2 & -2 receptors (response is generally inhibitory) o
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