Renal drugs Potassium sparing diuretics

Renal drugs Potassium sparing diuretics - diuetics such as...

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Renal drugs Potassium sparing diuretics Act on aldosterone responsive parts of nephron (distal tubule). Aldosterone stimulates Na+ reabsorption and the excretion of K+ and H+. Spironolactone Aldosterone antagonist – reduces K+ secretion. Used in ascities, heart failure, nephrotic syndrome, primary hyperaldosteronism. Route : Oral. Side Effects: Hyperkalaemia, gynaecomastia, GI upset, impotence. Contraindications: HyperK+, HypoNa+, addisons, pregnancy and breast feeding. Monitor: K+ Interactions : Other drugs that increase K+ - amiloride, ACEI, ARB and ciclosporin. Increases digoxin and lithium levels. Amiloride Weak K+ sparing diuretic. Works by blocking Na+ channels. May be given in combination with K+ wasting
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Unformatted text preview: diuetics such as furosemide (co-amilofruse) or thiazides ( co-amilozide) Side Effects/Contraindications/Interactions: As for spironolactone. Osmotic diuretics Mannitol Unlike other diuretics can cross blood-brain barrier so is used for cerebral oedema (also glaucoma) Dose/route: 0.25-2g/kg as rapid IV infusion Side Effects: GI upset, fever, oedema Contraindications: Pulmonary oedema, heart failure – as extract water from intracellular to extracelluar compartment will make these conditions worse....
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Renal drugs Potassium sparing diuretics - diuetics such as...

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