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Unformatted text preview: Carbonic anhydrase inhibitors Reduce bicarbonate reabsorption in the proximal tubule Leads to increased excretion of HCO3, Na and H2O. Increased Na+ delivery to distal nephron also increases excretion of K+. Acetazolamide Used in glaucoma (exerts effects on aqueous humour to reduce intra-ocular pressure). Prophylaxis for altitude sickness. Dose/route: 0.25-1g PO/IV (can cause necrolysis if given IV) Side Effects: GI upset, drowsiness , headache, derranged LFTs, if prolonged use can cause acidosis and electrolyte disturbance. Contraindications: HypoK+, HypoNa+, Hyperchloraemic acidosis, severe liver or renal disease. Monitor: Potassium and glucose especially if IV or high dose....
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This note was uploaded on 12/04/2011 for the course ANTHRO 2000 taught by Professor Monicaoyola during the Fall '10 term at Broward College.
- Fall '10