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Renin - Renin-angiotensin mechanism renin released by JG...

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Renin-angiotensin mechanism : renin released by JG cells converts angiotensinogen in plasma (made by liver) to angiotensin I, which is in turn converted to angiotensin II by angiotensin-converting enzyme (ACE) Angiotensin II is a potent vasoconstrictor that raises mean arterial blood pressure Angiotensin II also stimulates adrenal cortex to release aldosterone, which causes renal tubules to reabsorb more sodium ions from filtrate o Since water follows sodium, blood volume & blood pressure rise renin release is triggered by reduced stretch of JG cells, stimulation of JG cells by macula densa cells, direct stimulation of JG cells by epinephrine or norepinephrine, & direct stimulation of JG cells by angiotensin II o Tubular reabsorption : transepithelial process that reclaims most of tubule contents & returns them to blood Sodium reabsorption: primary active transport Sodium enters the tubule cell from the filtrate at the luminal membrane
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