Rheumatoid arthriti1

Rheumatoid arthriti1 - Rheumatoid arthritis Causes...

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Rheumatoid arthritis Causes Rheumatoid arthritis is a form of autoimmunity, the causes of which are still incompletely known. It is a systemic disorder principally affecting synovial tissues. Research suggests that the disease involves abnormal interactions between B-cells and T-cells. B cells present antigens to T cells via HLA-DR which elicits T-cell help, the consequence of which is production of Rheumatoid Factor (RF) and Antibodies to Citrullinated Peptides (ACPA). Inflammation is then driven either by B cell or T cell products stimulating release of TNF and other cytokines. It has long been suspected that certain infections could be triggers for this disease. The "mistaken identity" theory suggests that an infection triggers an immune response, leaving behind antibodies that should be specific to that organism. The antibodies are not sufficiently specific, though, and set off an immune attack against part of the host. Another potential trigger is smoking. Epidemiology
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Rheumatoid arthriti1 - Rheumatoid arthritis Causes...

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