Spina bifida Causes

Spina bifida Causes - dramatically with 0.15 per 1000 live...

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Spina bifida Causes The cause of Spina bifida is unknown but it is thought to be associated with:- Environmental factors o Low folic acid intake in women before conception and in the first few months of pregnancy is a risk factor o Folic acid is a B-group vitamin which is particularly important for foetal growth and closing of the foetal neural tube Genetic factors o The defect is thought to have a genetic component o If one parent has Spina bifida the chances of offspring being affected are between 1 and 5%. This increases to 15% if both parents are affected Epidemiology Spina bifida affects 1 in 1,000 babies. Between 5-10% of the population have Spina bifida occulta. The highest incidence rates worldwide were found in Ireland and Wales, where 3–4 cases of Myelomeningocele per 1000 population have been reported during the 1970s, along with more than six cases of anencephaly (both live births and stillbirths) per 1000 population. The reported overall incidence of Myelomeningocele in the British Isles was 2–3.5 cases per 1000 births. Since then, the rate has fallen
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Unformatted text preview: dramatically with 0.15 per 1000 live births reported in 1998, though this decline is partially accounted for by the fact that some foetuses are aborted when tests show signs of Spina bifida. Diagnosis Spina bifida can be diagnosed at different stages using various methods:- Blood tests can be carried out in pregnancy. A raised alpha-fetoprotein is associated with the defect Ultrasound scars are routinely performed at 11-20 weeks to look for and confirm the diagnosis CT or MRI scans will be performed after birth to assess the severity of the defect Clinical examination of the eyes can reveal swollen optic discs (Papilloedema) an indicator of hydrocephalus X-rays in people with Spina bifida occulta there may be no visible signs and the defect may be detected by chance later in life when investigating other conditions such as back pain...
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Spina bifida Causes - dramatically with 0.15 per 1000 live...

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