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Unformatted text preview: The diagnosis of thalassaemia depends on the clincal history and examination, combined with blood tests. On examination, the child may appear very pale. If the spleen is enlarged, the abdomen may also be distended. If the illness is not treated, the bones of the skull and hands may also be noticably enlarged. Blood tests reveal:- Low haemoglobin levels o These may be as low as 2-8g/l o Beta-thalassaemia trait patients may have mild background anaemia or become anaemia at stressful times o WCC and platelets may also be low if the spleen is enlarged Other investigations include:- Electrophoresis used to reveal abnormal haemoglobin Boremarrow biopsy may show over production of immature RBCs Post-mortem carried out in still borne babies to identify the cause of death...
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- Fall '10