Vasculitides - MRA o to look for filling defects,...

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Vasculitides This article explores the vasculitides, what they are and how to deal with them. Introduction Vasculitides: what are they? A group of diseases which affect the blood vessel wall causing inflammation. Giant cells in the media release lytic compounds which cause the artery to break down. May be primary (e.g. wegeners) or secondary to other diseases (Rheumatoid arthritis, SLE) or infections. The symptoms can be predicted depending on the size of vessels that are generally affected (see the table below). Systemic symptoms include: fever, malaise, weight loss, arthralgia and myalgia Clue to a vasculitic cause Punched out ulcers in odd places (with skin necrotizing around not healing) Investigations In addition to the usual standard blood tests also include:
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Unformatted text preview: MRA o to look for filling defects, aneurysms, patchiness Inflammatory markers o ESR & CRP ANCA Urine Dipstick and microscopy Treatment Treatment Usually treat aggressively with immunosuppressives monoclonal antibodies Methotrexate, cyclophosphamide, azathioprine Polymyalgia Rheumatica Not a true vasculitis. Presents with 2 weeks or less symmetrical aching, tenderness and morning stiffness particularly in the shoulders and proximal limb muscles. The muscles are STIFF NOT WEAK. Also get fever, weight loss, anorexia, depression, polyarthritis and carpal tunnel. Treatment requires Prednisolone for 2 years (with bisphosphonates to protect bones)....
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This note was uploaded on 12/04/2011 for the course ANTHRO 2000 taught by Professor Monicaoyola during the Fall '10 term at Broward College.

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Vasculitides - MRA o to look for filling defects,...

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