Lecture_3_molecular_forces_2011

Lecture_3_molecular_forces_2011 - Introduction to...

Info iconThis preview shows pages 1–6. Sign up to view the full content.

View Full Document Right Arrow Icon
Introduction to Biophysics Lecture 3 Molecular forces in Biological Structures
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
non-covalent interactions Electrostatic interaction Charge – dipole interaction Induced Dipoles Cation - π interaction Dispersion forces Hydrophobic forces Hydration forces Hydrogen bounds Steric repulsion
Background image of page 2
Electrostatic self energy: The energy of placing ion in a dielectric medium. Consider the work done to bring a small increment of charge δ q’ to the surface of a sphere with radius r, already carrying a charge, q’ This charging process can be integrated to get the total work done, starting with charge = 0 and final charge = q. This equation can be used to estimate the free energy (F) of placing an ion in a solvent with particular dielectric constant. Find a difference between the electrostatic self-energy for ion (Na + , r=0.95Å) in two media (water and hydrocarbon(membrane)) and estimate the free energy of transfer of Na + ions between two media. Give a answer in k B T and kcal mole -1
Background image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Can we predict partition - (P) or distribution coefficient (D) (the ratio of concentrations of a compound in the two phases of a mixture of two immiscible solvents at equilibrium.) of charged particle (ion) in water/hydrocarbon system by knowing its electrostatic self-energy?
Background image of page 4
Discrete distribution Probability of observing x i N i /N =P(x i ) for large N Σ i P(x i ) = 1 normalization condition Continuous distributions Bins of width d x dN (x 0
Background image of page 5

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Image of page 6
This is the end of the preview. Sign up to access the rest of the document.

Page1 / 18

Lecture_3_molecular_forces_2011 - Introduction to...

This preview shows document pages 1 - 6. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online