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Lecture_4_H-bonds

Lecture_4_H-bonds - Introduction to Biophysics Lecture 4...

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Introduction to Biophysics Lecture 4 Water Hydrophobic interactions
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Water unusual properties such as a negative change in volume with melting, a high dielectric constant, a high melting point, a high freezing point, a high heat capacity. Why? d=1.85 D – dipole moment and intermolecular H-bonds Thus H-atom in one molecule can interact with any electronegative atom (O, N, F) in another molecule. 1920 M. Huggins/ G. Lewis
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Water H-bonds result in 3D network 2 x (O-H) = 0.97 Å 2 x (O-H) = 1.77 Å 2.6 Å – sum of O and H atomic radii Van der Waals attraction for 2 small neutral molecules 0.6-1.6 k B T r True chemical bond 90-350 k B T r 2 water molecules in vapor 9 k B T r If you want to dissolve substance in water, molecules will perturb/break H-bonds structure
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H-bonds in biological structures
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Formation of double helix is highly cooperative process
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H-bonds in biological structures An intramolecular hydrogen bond between two groups within a protein (or protein with ligand) forms at the expense of two hydrogen bonds with water.
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